Abstract
Molecular systems biology seeks to explain the behavior of complex cellular systems through a multicomponent analysis. We illustrate this approach and its relevance to drug development by reviewing two examples of the interplay between cellular processes and drugs: the internalization and recycling of oncogenic receptors, their ligands and therapeutic antibodies; and strategies for discovering drugs that affect intracellular protein kinase pathways.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / pharmacology*
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents / pharmacology
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Drug Design*
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ErbB Receptors / metabolism*
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Humans
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Ligands
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Molecular Biology*
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Phenotype
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Receptor, ErbB-2 / metabolism*
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Signal Transduction*
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Systems Biology*
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Trastuzumab
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents
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Ligands
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ERBB2 protein, human
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ErbB Receptors
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Receptor, ErbB-2
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Trastuzumab