Climate change is increasing the burden of climate-sensitive health determinants and outcomes worldwide. Acting through increasing temperature, changes in the hydrologic cycle, and sea level rise, climate change is projected to increase the frequency and intensity of heat events and extreme events (floods and droughts), change the geographic range and incidence of climate-sensitive vector-, food-, and waterborne diseases, and increase diseases associated with air pollution and aeroallergens. Children are particularly vulnerable to these health outcomes because of their potentially greater exposures, greater sensitivity to certain exposures, and their dependence on caregivers.