Abstract
Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arteries / drug effects*
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Cattle
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Chemistry, Pharmaceutical / methods*
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Dose-Response Relationship, Drug
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Drug Design
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Eicosanoids / chemical synthesis*
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Eicosanoids / pharmacology*
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Furans / chemistry*
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Models, Chemical
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Molecular Conformation
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Oxygenases / chemistry*
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Stereoisomerism
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Vasodilation / drug effects
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Vasodilator Agents / chemical synthesis*
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Vasodilator Agents / pharmacology*
Substances
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Eicosanoids
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Furans
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Vasodilator Agents
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tetrahydrofuran
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Oxygenases