Electrophysiological studies of malaria parasite-infected erythrocytes: current status

Int J Parasitol. 2007 Apr;37(5):475-82. doi: 10.1016/j.ijpara.2006.12.013. Epub 2007 Jan 9.

Abstract

The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Anions / metabolism
  • Cell Membrane Permeability / drug effects
  • Cell Membrane Permeability / physiology*
  • Dantrolene / pharmacology
  • Erythrocytes / parasitology*
  • Erythrocytes / physiology
  • Furosemide / pharmacology
  • Humans
  • Ion Channels / physiopathology
  • Malaria, Falciparum / parasitology*
  • Malaria, Falciparum / physiopathology
  • Membrane Transport Modulators / pharmacology
  • Nitrobenzoates / pharmacology
  • Oxidation-Reduction
  • Patch-Clamp Techniques
  • Plasmodium falciparum / physiology

Substances

  • Anions
  • Ion Channels
  • Membrane Transport Modulators
  • Nitrobenzoates
  • 5-nitro-2-(3-phenylpropylamino)benzoic acid
  • Furosemide
  • Dantrolene