SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population

C Babb; E Hanekom Keet; P D van Helden; E G Hoal

doi:10.1007/s00439-007-0335-1

SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population

Hum Genet. 2007 May;121(3-4):521-2. doi: 10.1007/s00439-007-0335-1. Epub 2007 Feb 8.

Authors

C Babb¹, E Hanekom Keet, P D van Helden, E G Hoal

Affiliation

¹ Molecular Biology and Human Genetics, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa.

PMID: 17287948
DOI: 10.1007/s00439-007-0335-1

Abstract

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the Ipr1 gene. Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. We investigated eight SP110 polymorphisms in a South African population, including two novel polymorphisms. No significant association was found with any of the polymorphisms investigated, including two polymorphisms that were previously found to be associated with TB susceptibility in West African populations.

MeSH terms

Adolescent
Black People / genetics
Case-Control Studies
Genetic Predisposition to Disease
Humans
Minor Histocompatibility Antigens
Nuclear Proteins / genetics*
Polymorphism, Genetic*
Tuberculosis, Pulmonary / genetics*

Substances

Minor Histocompatibility Antigens
Nuclear Proteins
Sp110 protein, human