Epstein-Barr virus early-antigen antibodies before allogeneic haematopoietic stem cell transplantation as a marker of risk of post-transplant lymphoproliferative disorders

Br J Haematol. 2007 Jan;136(2):305-8. doi: 10.1111/j.1365-2141.2006.06420.x.

Abstract

The occurrence of post-transplant lymphoproliferative disorders (PTLDs) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents a clinical problem. Pretransplant Epstein-Barr virus serological status and viral load was determined in 21 recipients and 28 control transplanted patients, with (+) and without (-) PTLD, respectively. Early-antigen immunoglobulin G (EA-IgG) was detected in 12/21 PTLD+ patients, but only 2/28 PTLD patients (P = 0.00023, Odds ratio = 17.42). High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development.

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Aplastic / surgery
  • Anemia, Aplastic / virology
  • Antibodies, Viral / blood*
  • Antigens, Viral / immunology*
  • Biomarkers / blood
  • Case-Control Studies
  • Cell Count
  • Child
  • Child, Preschool
  • Epstein-Barr Virus Infections / diagnosis*
  • Fanconi Anemia / surgery
  • Fanconi Anemia / virology
  • Female
  • Flow Cytometry
  • Hematopoietic Stem Cell Transplantation*
  • Herpesvirus 4, Human*
  • Humans
  • Leukemia / surgery
  • Leukemia / virology
  • Lymphoproliferative Disorders / etiology*
  • Lymphoproliferative Disorders / virology
  • Male
  • Middle Aged
  • Multiple Myeloma / surgery
  • Multiple Myeloma / virology
  • Odds Ratio
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Serologic Tests
  • Transplantation, Homologous
  • Viral Load

Substances

  • Antibodies, Viral
  • Antigens, Viral
  • Biomarkers
  • Epstein-Barr virus early antigen