First linezolid-resistant clinical isolates of Mycobacterium tuberculosis

Elvira Richter; Sabine Rüsch-Gerdes; Doris Hillemann

doi:10.1128/AAC.01113-06

First linezolid-resistant clinical isolates of Mycobacterium tuberculosis

Antimicrob Agents Chemother. 2007 Apr;51(4):1534-6. doi: 10.1128/AAC.01113-06. Epub 2007 Jan 22.

Authors

Elvira Richter¹, Sabine Rüsch-Gerdes, Doris Hillemann

Affiliation

¹ Forschungszentrum Borstel, National Reference Center for Mycobacteria, Parkallee 18, D-23845 Borstel, Germany.

Abstract

Linezolid resistance was found in 4 (1.9%) of 210 multidrug-resistant Mycobacterium tuberculosis strains. The MICs of linezolid were 4 microg/ml (one strain) and 8 microg/ml (three strains). Since no mutations were detected in potential target genes, the mechanism of resistance remains unclear.

MeSH terms

Acetamides / pharmacology*
Antitubercular Agents / pharmacology
Drug Resistance, Bacterial / genetics
Drug Resistance, Bacterial / physiology
Humans
Linezolid
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / isolation & purification
Oxazolidinones / pharmacology*
Tuberculosis, Multidrug-Resistant*

Substances

Acetamides
Antitubercular Agents
Oxazolidinones
Linezolid