Tyrosine phosphatases in steroidogenic cells: regulation and function

Alejandra Gorostizaga; Fabiana Cornejo Maciel; Laura Brion; Paula Maloberti; Ernesto J Podestá; Cristina Paz

doi:10.1016/j.mce.2006.12.009

Tyrosine phosphatases in steroidogenic cells: regulation and function

Mol Cell Endocrinol. 2007 Feb:265-266:131-7. doi: 10.1016/j.mce.2006.12.009. Epub 2007 Jan 5.

Authors

Alejandra Gorostizaga¹, Fabiana Cornejo Maciel, Laura Brion, Paula Maloberti, Ernesto J Podestá, Cristina Paz

Affiliation

¹ Department of Biochemistry, School of Medicine, University of Buenos Aires, Paraguay 2155, 5th (C1121ABG) Buenos Aires, Argentina.

PMID: 17207923
DOI: 10.1016/j.mce.2006.12.009

Abstract

In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein phosphatase (serine/threonine and tyrosine). This work summarizes the knowledge on the regulation and the role played by cAMP-activated tyrosine phosphatases as well as MKP-1 in the hormonal activation of the acute and chronic phases of steroidogenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adrenal Cortex / cytology
Adrenal Cortex / metabolism*
Animals
Cyclic AMP-Dependent Protein Kinases / metabolism
Gene Expression Regulation
Humans
Leydig Cells / metabolism*
Male
Protein Phosphatase 1
Protein Tyrosine Phosphatases / genetics
Protein Tyrosine Phosphatases / metabolism*
Steroids / biosynthesis*
Transcription, Genetic

Substances

Steroids
Cyclic AMP-Dependent Protein Kinases
Protein Phosphatase 1
Protein Tyrosine Phosphatases