Anthropometric determinants of a clustering of lipid-related metabolic risk factors in overweight and non-overweight adolescents--influence of cardiorespiratory fitness. The Avena study

Ann Nutr Metab. 2006;50(6):519-27. doi: 10.1159/000098144. Epub 2006 Dec 21.

Abstract

Background/aims: To explore in adolescents the associations between simple anthropometric variables with a continuously distributed summary score for lipid-related metabolic risk in both overweight and non-overweight adolescents, and to test whether these associations are modified by the level of cardiorespiratory fitness.

Methods: Cardiorespiratory fitness, BMI, skinfold thicknesses, body circumferences, and a continuously distributed clustering of lipid- related metabolic risk (calculated from LDL and HDL cholesterol, triglycerides, and glucose) were measured in 524 adolescents (265 males, 259 females, 15.3 +/- 1.4 years) from the cross-sectional multicentric AVENA study. Participants were classified as overweight (including obesity) or non-overweight.

Results: Most anthropometric parameters were univariately related to the continuous lipid-related metabolic risk. However, after multicollinear analysis and generalized linear modelling, suprailiac skinfold thickness in males (p < 0.001, explained variance 12.2%) and waist-to-height ratio in females (p < 0.001, explained variance 10.0%) were the best determinants of the continuous metabolic risk score, after adjustment for age, sexual maturation, and economic status. These associations were slightly weakened in overweight males (p = 0.034) and females (p = 0.087), and did not interact with cardiorespiratory fitness.

Conclusion: Our data emphasize the usefulness of suprailiac skinfold thickness in males and waist-to-height ratio in females as simple anthropometric measurements associated to an overall lipid-related metabolic risk, mainly in non-overweight adolescents and regardless their cardiorespiratory status.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anthropometry*
  • Blood Glucose / analysis
  • Body Height
  • Body Mass Index
  • Body Weight
  • Cardiovascular Physiological Phenomena
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Cluster Analysis
  • Cross-Sectional Studies
  • Humans
  • Hyperglycemia / epidemiology
  • Hyperlipidemias / epidemiology
  • Lipid Metabolism*
  • Obesity / epidemiology*
  • Physical Fitness*
  • Respiratory Physiological Phenomena
  • Risk Assessment
  • Risk Factors
  • Sex Factors
  • Skinfold Thickness
  • Spain / epidemiology
  • Triglycerides / blood
  • Waist-Hip Ratio

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides