Lipid cartography of atherosclerotic plaque by cluster-TOF-SIMS imaging

Analyst. 2007 Jan;132(1):24-6. doi: 10.1039/b614619h. Epub 2006 Nov 21.

Abstract

Several frozen vessels bearing atherosclerotic lesion were analysed by cluster TOF-SIMS (time-of-flight secondary ion mass spectrometry) to map their lipid (fatty acids, cholesterol, vitamin E, phosphatidic acids, phosphatidylinositols and triglycerides) content at a micrometric resolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atherosclerosis / metabolism*
  • Carotid Arteries / chemistry*
  • Cholesterol / analysis
  • Fatty Acids / analysis
  • Humans
  • Lipids / analysis*
  • Male
  • Phosphatidic Acids / analysis
  • Phosphatidylinositols / analysis
  • Spectrometry, Mass, Secondary Ion*
  • Triglycerides / analysis
  • Vitamin E / analysis

Substances

  • Fatty Acids
  • Lipids
  • Phosphatidic Acids
  • Phosphatidylinositols
  • Triglycerides
  • Vitamin E
  • Cholesterol