[Process of complexation of prothrombine and fibrin E-fragment]

Ukr Biokhim Zh (1999). 2006 May-Jun;78(3):99-105.
[Article in Ukrainian]

Abstract

The study is devoted to research of the blood coagulation key proenzyme complexation process. It is prothrombin, and the E-fragment of fibrin can be a component in blood circulation. It is shown, that non-enzyme activation of prothrombin by the E-fragment proceeds as a result of formation of stable non-covalent prothrombin-E fragment complex. The cringle structures of prothrombin and the N-terminal site of beta-chain of E-fragment of fibrin are important for formation of the given complex. It has been defined, that other fragments of fibrin (D and DD) are not capable to induce amydolytic activity of prothrombin.

Publication types

  • English Abstract

MeSH terms

  • Blood Coagulation / physiology
  • Blotting, Western
  • Chromatography, Gel
  • Fibrin Fibrinogen Degradation Products / chemistry*
  • Fibrin Fibrinogen Degradation Products / physiology
  • Humans
  • In Vitro Techniques
  • Prothrombin / chemistry*
  • Prothrombin / physiology

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • fibrin fragment E-2
  • Prothrombin