Keeping transcriptional activators under control

Thomas Kodadek; Devanjan Sikder; Kip Nalley

doi:10.1016/j.cell.2006.10.002

Keeping transcriptional activators under control

Cell. 2006 Oct 20;127(2):261-4. doi: 10.1016/j.cell.2006.10.002.

Authors

Thomas Kodadek¹, Devanjan Sikder, Kip Nalley

Affiliation

¹ Department of Internal Medicine , University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390, USA. thomas.kodadek@utsouthwestern.edu

PMID: 17055428
DOI: 10.1016/j.cell.2006.10.002

Abstract

Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Humans
Models, Genetic
Proteasome Endopeptidase Complex / metabolism*
Protein Processing, Post-Translational*
Time Factors
Trans-Activators / metabolism*
Transcription, Genetic / physiology
Transcriptional Activation*
Ubiquitin / metabolism*

Substances

Trans-Activators
Ubiquitin
Proteasome Endopeptidase Complex

Abstract

Publication types

MeSH terms

Substances

Grants and funding