Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506

Transplant Proc. 1991 Feb;23(1 Pt 2):928-30.

Abstract

FK 506 therapy with low doses of steroids was adequate to control rejection in most liver recipients. Rejection episodes were readily reversed with single IV doses of methylprednisone or hydrocortisone. Short courses of OKT3 (3 to 5 days 5-10 mL) controlled severe rejections. The rate of retransplantation directly due to rejection was low (1.6%). There was a limited need for steroids either early or out to 6 to 12 months.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use
  • Graft Rejection
  • Humans
  • Hydrocortisone / administration & dosage
  • Immunosuppression Therapy / methods*
  • Immunosuppressive Agents*
  • Liver Diseases / surgery
  • Liver Transplantation / methods*
  • Methylprednisolone / administration & dosage
  • Muromonab-CD3
  • Survival Analysis
  • Tacrolimus

Substances

  • Anti-Bacterial Agents
  • Antibodies, Monoclonal
  • Immunosuppressive Agents
  • Muromonab-CD3
  • Hydrocortisone
  • Tacrolimus
  • Methylprednisolone