Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID

Neurology. 2006 Oct 10;67(7):1275-8. doi: 10.1212/01.wnl.0000238506.76873.2f.

Abstract

The WASID trial showed no advantage of warfarin over aspirin for preventing the primary endpoint of ischemic stroke, brain hemorrhage, or vascular death. In analyses of selected subgroups, there was no definite benefit from warfarin. Warfarin reduced the risk of the primary endpoint among patients with basilar artery stenosis, but there was no reduction in stroke in the basilar artery territory or benefit for vertebral artery stenosis or posterior circulation disease in general.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Anticoagulants / therapeutic use
  • Aspirin / therapeutic use*
  • Cerebral Arterial Diseases / diagnosis
  • Cerebral Arterial Diseases / drug therapy*
  • Cerebral Arterial Diseases / mortality*
  • Constriction, Pathologic / diagnosis
  • Constriction, Pathologic / drug therapy
  • Constriction, Pathologic / mortality
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Assessment / methods*
  • Risk Factors
  • Survival Analysis
  • Survival Rate
  • Treatment Outcome
  • United States / epidemiology
  • Warfarin / therapeutic use*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticoagulants
  • Warfarin
  • Aspirin