Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect

A Takami; H Takamatsu; H Yamazaki; K Ishiyama; H Okumura; K Ohata; H Konaka; H Asakura; M Namiki; S Nakao

doi:10.1038/sj.bmt.1705519

Reduced-intensity unrelated cord blood transplantation for treatment of metastatic renal cell carcinoma: first evidence of cord-blood-versus-solid-tumor effect

Bone Marrow Transplant. 2006 Dec;38(11):729-32. doi: 10.1038/sj.bmt.1705519. Epub 2006 Oct 9.

Authors

A Takami¹, H Takamatsu, H Yamazaki, K Ishiyama, H Okumura, K Ohata, H Konaka, H Asakura, M Namiki, S Nakao

Affiliation

¹ Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan. takami@med3.m.kanazawa-u.ac.jp

PMID: 17028623
DOI: 10.1038/sj.bmt.1705519

Abstract

We report a 69-year-old man with cytokine-resistant metastatic renal cell carcinoma treated with reduced-intensity unrelated cord blood transplantation. The patient achieved durable donor engraftment with minimal graft-versus-host disease. The patient showed regression of metastatic disease, providing the first evidence of a graft-versus-tumor effect on a solid tumor resulting from cord blood graft.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Carcinoma, Renal Cell / pathology
Carcinoma, Renal Cell / therapy*
Cord Blood Stem Cell Transplantation*
Graft vs Host Disease / complications
Graft vs Tumor Effect*
Humans
Kidney Neoplasms / pathology
Kidney Neoplasms / therapy*
Male
Neoplasm Metastasis / therapy
Transplantation Conditioning / methods*
Transplantation, Homologous
Treatment Outcome