The chemokine receptor CXCR4 as a therapeutic target for several diseases

Hirokazu Tamamura; Hiroshi Tsutsumi; Nobutaka Fujii

doi:10.2174/138955706778195135

The chemokine receptor CXCR4 as a therapeutic target for several diseases

Mini Rev Med Chem. 2006 Sep;6(9):989-95. doi: 10.2174/138955706778195135.

Authors

Hirokazu Tamamura¹, Hiroshi Tsutsumi, Nobutaka Fujii

Affiliation

¹ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. tamamura.mr@tmd.ac.jp

PMID: 17017998
DOI: 10.2174/138955706778195135

Abstract

CXCR4 is the receptor for a chemokine, CXCL12 (stromal cell-derived factor-1, SDF-1). The CXCL12-CXCR4 axis has been proven to be involved in several problematic diseases, including AIDS, cancer cell metastasis, leukemia cell progression and rheumatoid arthritis (RA). Thus, CXCR4 is thought to be an important therapeutic target to overcome the above diseases. We have developed several specific CXCR4 antagonists.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
HIV Infections / drug therapy*
HIV Infections / metabolism
Humans
Neoplasms / drug therapy*
Neoplasms / metabolism
Receptors, CXCR4 / antagonists & inhibitors*
Receptors, CXCR4 / metabolism*

Substances

Anti-HIV Agents
Antineoplastic Agents
Receptors, CXCR4