Cytokeratin expression in malignant Triton tumor

Pathol Res Pract. 1990 Aug;186(4):507-11; discussion 511-3. doi: 10.1016/S0344-0338(11)80470-X.

Abstract

A malignant Triton tumor in a 9-year-old boy is described. The first biopsy which was taken from the thenar prominence was diagnosed as a monophasic fibrous synovial sarcoma based on the finding of a spindle cell neoplasm with plump nuclei and cytokeratin expression. The true nature of the tumor became apparent when a second biopsy was investigated. In this specimen a rhabdomyosarcomatous component was found in association with a spindle cell sarcoma fulfilling the criteria of a malignant schwannoma. Immunohistochemical staining using antibodies against vimentin, desmin, muscle-specific actin, cytokeratin, glial fibrillary acidic protein, protein S-100, Leu 7 and myoglobin served to distinguish the two tumor components and documented the possible reactivity of malignant Triton tumor for cytokeratins.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Child
  • Hand
  • Humans
  • Immunoenzyme Techniques
  • Keratins / analysis*
  • Male
  • Neurilemmoma / chemistry*
  • Neurilemmoma / pathology

Substances

  • Keratins