Modular asymmetric synthesis of 1,2-diols by single-pot allene diboration/hydroboration/cross-coupling

Org Lett. 2006 Sep 28;8(20):4557-9. doi: 10.1021/ol0616891.

Abstract

Chiral allyl vinyl boronates are generated by catalytic enantioselective diboration of prochiral allenes. They may then be reacted, in situ, with a hydroborating reagent to form a novel triboron intermediate. The least hindered and most reactive C-B bond then participates in cross-coupling wherein the coupling is brought about by the same catalyst as that which catalyzed the diboration reaction. The remaining C-B bonds are then oxidized in the reaction workup, thereby allowing for the modular synthesis of chiral diols in a concise single-pot fashion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkadienes / chemistry
  • Boron Compounds / chemistry*
  • Catalysis
  • Stereoisomerism

Substances

  • Alkadienes
  • Boron Compounds
  • propadiene