Tuberculosis treatment duration in France: From guidelines to daily practice

P Tattevin; J-M Chapplain; P Lesprit; C Billy; F Roblot; S Alfandari; L Bernard; E Rouveix; E Bouvet

doi:10.1016/j.ejim.2006.02.021

Tuberculosis treatment duration in France: From guidelines to daily practice

Eur J Intern Med. 2006 Oct;17(6):427-9. doi: 10.1016/j.ejim.2006.02.021.

Authors

P Tattevin¹, J-M Chapplain, P Lesprit, C Billy, F Roblot, S Alfandari, L Bernard, E Rouveix, E Bouvet

Affiliation

¹ CHU Pontchaillou, 35033, Rennes, France.

PMID: 16962951
DOI: 10.1016/j.ejim.2006.02.021

Abstract

Background: Guidelines for tuberculosis (TB) recommend 6 months of treatment except for meningeal TB, where a 9- to 12-month course may be preferred.

Methods: In order to assess whether practices in France are in agreement with those guidelines, we performed an anonymous audit of the policy of French physicians, focusing on TB treatment duration and corticosteroid use according to the TB presentation.

Results: Sixty-six completed forms were analyzed. Reported treatment duration was usually 6 months for pulmonary TB (91% of physicians) and miliary TB (45%), 9 months for pulmonary TB in HIV-infected patients (42%) and for TB lymphadenitis (57%), and 12 months for TB meningitis (79%) and osteo-articular TB (65%). Corticosteroid use was systematic for meningitis (80%) and pericarditis (65%).

Conclusion: This study reveals discrepancies between guidelines and daily practice for TB treatment duration in France: We observed a very high reported rate of unnecessary, prolonged treatment for most extrapulmonary TB.