The FEZ1 gene shows no association to schizophrenia in Caucasian or African American populations

Neuropsychopharmacology. 2007 Jan;32(1):190-6. doi: 10.1038/sj.npp.1301177. Epub 2006 Aug 16.

Abstract

Schizophrenia is a complex psychiatric disorder with both genetic and environmental components and is thought to be in part neurodevelopmental in origin. The DISC1 gene has been linked to schizophrenia in two independent Caucasian populations. The DISC1 protein interacts with a variety of proteins including FEZ1, the mammalian homolog of the Caenorhabditis elegans unc-76 protein, which is involved in axonal outgrowth. Variation at the FEZ1 gene has been associated with schizophrenia in a large Japanese cohort. In this study, nine SNP markers at the FEZ1 locus were genotyped in two populations. A North American Caucasian cohort of 212 healthy controls, 178 schizophrenics, 79 bipolar disorder, and 58 with schizoaffective disorder, and an African American cohort of 133 healthy controls, 162 schizophrenics, and 28 with schizoaffective disorder. No association to schizophrenia, bipolar disorder or schizoaffective disorder was found for any of the nine markers typed in these populations at the allelic or the genotypic level. Additionally no association was found in either population between specific haplotypes and any of the psychiatric disorders. Variation at the FEZ1 locus does not play a significant role in the etiology of schizophrenia, bipolar disorder or schizoaffective disorder in North American Caucasian or African American populations.Neuropsychopharmacology (2007) 32, 190-196. doi:10.1038/sj.npp.1301177; published online 16 August 2006.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Bipolar Disorder / genetics
  • Black or African American / genetics
  • Cohort Studies
  • DNA-Binding Proteins / genetics*
  • Genotype
  • Humans
  • Nerve Tissue Proteins
  • Polymorphism, Single Nucleotide
  • Psychotic Disorders / genetics
  • Schizophrenia / genetics*
  • Tumor Suppressor Proteins / genetics*
  • White People / genetics

Substances

  • Adaptor Proteins, Signal Transducing
  • DNA-Binding Proteins
  • FEZ1 protein, human
  • LZTS1 protein, human
  • Nerve Tissue Proteins
  • Tumor Suppressor Proteins