A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2

J Antibiot (Tokyo). 2006 Jun;59(6):362-5. doi: 10.1038/ja.2006.52.

Abstract

A new diphenyl ether dimethyl 2,3'-dimethylosoate (1) together with three known compounds monomethylsulochrin (2), emodin (3), and questin (4) were isolated through bioassay-guided fractionations from the culture of a marine-derived fungus Aspergillus sp. B-F-2. The structures of these compounds were determined by spectroscopic methods. Cytotoxicities of compounds 1 and 2 against K562 cell line were preliminarily evaluated by the MTT method and flow cytometry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Apoptosis / drug effects
  • Aspergillus / metabolism*
  • Humans
  • K562 Cells
  • Phenyl Ethers / chemistry
  • Phenyl Ethers / isolation & purification*
  • Phenyl Ethers / pharmacology
  • Water Microbiology*

Substances

  • Antibiotics, Antineoplastic
  • Phenyl Ethers
  • phenyl ether