Abstract
Long-chain fatty acids are both important metabolites as well as signaling molecules. Fatty acid transport proteins are key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Animals, Genetically Modified
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Biological Transport / physiology
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Fatty Acid Transport Proteins / genetics
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Fatty Acid Transport Proteins / physiology*
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Fatty Acids / metabolism*
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Homeostasis / physiology
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Humans
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Insulin Resistance / physiology
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Mice
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Mice, Knockout
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Models, Animal
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Obesity / physiopathology
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Polymorphism, Genetic / genetics
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Signal Transduction / physiology
Substances
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Fatty Acid Transport Proteins
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Fatty Acids