Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS

Neurology. 2006 Jun 27;66(12):1929-31. doi: 10.1212/01.wnl.0000219756.71928.25.

Abstract

Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5'UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependent on the sex ratio of the sample.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Amyotrophic Lateral Sclerosis / epidemiology*
  • Amyotrophic Lateral Sclerosis / genetics*
  • Cohort Studies
  • DNA Mutational Analysis
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing / methods*
  • Germany / epidemiology
  • Heterozygote
  • Humans
  • Male
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide / genetics
  • Prevalence
  • Risk Assessment / methods*
  • Risk Factors
  • Sex Distribution
  • Sex Factors
  • Statistics as Topic
  • Vascular Endothelial Growth Factor A / genetics*

Substances

  • Vascular Endothelial Growth Factor A