Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

Patrick Y Wen; Santosh Kesari; Jan Drappatz

doi:10.1586/14737140.6.5.733

Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment

Expert Rev Anticancer Ther. 2006 May;6(5):733-54. doi: 10.1586/14737140.6.5.733.

Authors

Patrick Y Wen¹, Santosh Kesari, Jan Drappatz

Affiliation

¹ Harvard Medical School, Dana-Farber/Brigham and Women's Cancer Center, SW430D, Boston, MA 02115, USA. pwen@partners.org

PMID: 16759164
DOI: 10.1586/14737140.6.5.733

Abstract

Recently, there has been increasing interest in the use of targeted molecular agents for the treatment of malignant gliomas. These agents are generally well tolerated but have demonstrated only modest activity. In this article, the current status of targeted molecular agents for malignant gliomas will be reviewed and strategies to improve their effectiveness will be discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain Neoplasms / drug therapy*
Brain Neoplasms / genetics*
Brain Neoplasms / physiopathology
Clinical Trials as Topic
Enzyme Inhibitors
Glioma / drug therapy*
Glioma / genetics*
Glioma / physiopathology
Growth Inhibitors
Growth Substances
Humans

Substances

Enzyme Inhibitors
Growth Inhibitors
Growth Substances