Abstract
The authors examined cognitive performance change in 101 individuals with advanced HIV infection on highly active antiretroviral therapy (HAART), using standard neuropsychological testing in three visits, over a 27-month-period. Cognitive performance stabilized in a majority of HIV+ participants over time. A neuroactive HAART regimen was associated with neuropsychological improvement. Decline occurred in a minority with lower nadir CD4. The current CD4 count and plasma viral load were not associated with cognitive change.
MeSH terms
-
AIDS Dementia Complex / diagnosis
-
AIDS Dementia Complex / drug therapy*
-
AIDS Dementia Complex / prevention & control
-
AIDS Dementia Complex / psychology
-
Adult
-
Anti-HIV Agents / administration & dosage
-
Anti-HIV Agents / pharmacology
-
Anti-HIV Agents / therapeutic use*
-
Antiretroviral Therapy, Highly Active*
-
Attention / drug effects
-
CD4 Lymphocyte Count
-
Disease Progression
-
Female
-
HIV Infections / blood
-
HIV Infections / drug therapy
-
HIV Infections / psychology
-
Humans
-
Male
-
Memory / drug effects
-
Middle Aged
-
Neuropsychological Tests
-
Prevalence
-
Prospective Studies
-
Psychomotor Performance / drug effects
-
Sampling Studies
-
Verbal Learning / drug effects
-
Viral Load