Ectopic hamartomatous thymoma: a case report with immunohistochemical study and review of the literature

J Cutan Pathol. 2006 May;33(5):369-72. doi: 10.1111/j.0303-6987.2006.00424.x.

Abstract

Ectopic hamartomatous thymoma (EHT) is a rare benign tumor. We present a case of EHT, which was seen as subcutaneous mass on the left supraclavicular area in a 19-year-old man. The tumor consisted of spindle cells, epithelial cells, adipose cells, and a small amount of lymphocytes, as described previously. Immunohistochemically, spindle cells were positive for keratin, a-smooth muscle actin, CD34 and vimentin, but negative for desmin and S-100 protein. Lymphocytes were positive for CD45RO but negative for CD20, CD1a, and CD99. Approximately, 5% of cells were positive for MIB-1 and no cells stained for p53 and bcl-2. Recognition of EHT is important and needs to be differentiated from high-grade sarcomas such as synovial sarcoma or glandular malignant peripheral nerve sheath tumor.

Publication types

  • Case Reports

MeSH terms

  • 12E7 Antigen
  • Adult
  • Antigens, CD / metabolism
  • Antigens, CD1 / metabolism
  • Antigens, CD20 / metabolism
  • Antigens, CD34 / metabolism
  • Cell Adhesion Molecules / metabolism
  • Choristoma / metabolism
  • Choristoma / pathology*
  • Diagnosis, Differential
  • Hamartoma / metabolism
  • Hamartoma / pathology*
  • Humans
  • Keratins / metabolism
  • Leukocyte Common Antigens / metabolism
  • Male
  • Nerve Sheath Neoplasms / pathology
  • Sarcoma, Synovial / metabolism
  • Sarcoma, Synovial / pathology
  • Soft Tissue Neoplasms / metabolism
  • Soft Tissue Neoplasms / pathology*
  • Thymoma*
  • Thymus Neoplasms*
  • Vimentin / metabolism

Substances

  • 12E7 Antigen
  • Antigens, CD
  • Antigens, CD1
  • Antigens, CD20
  • Antigens, CD34
  • CD1a antigen
  • CD99 protein, human
  • Cell Adhesion Molecules
  • Vimentin
  • Keratins
  • Leukocyte Common Antigens