Molecular characterization and drug resistance testing of Mycobacterium tuberculosis isolates from Chad

Colette Diguimbaye; Markus Hilty; Richard Ngandolo; Hassane H Mahamat; Gaby E Pfyffer; Franca Baggi; Marcel Tanner; Esther Schelling; Jakob Zinsstag

doi:10.1128/JCM.44.4.1575-1577.2006

Molecular characterization and drug resistance testing of Mycobacterium tuberculosis isolates from Chad

J Clin Microbiol. 2006 Apr;44(4):1575-7. doi: 10.1128/JCM.44.4.1575-1577.2006.

Authors

Colette Diguimbaye¹, Markus Hilty, Richard Ngandolo, Hassane H Mahamat, Gaby E Pfyffer, Franca Baggi, Marcel Tanner, Esther Schelling, Jakob Zinsstag

Affiliation

¹ Swiss Tropical Institute, Socinstrasse 57, P.O. Box CH 4002, Basel, Switzerland.

Abstract

The molecular characterizations of the first 40 Mycobacterium tuberculosis isolates from Chad revealed a high proportion of isolates of the Cameroon family (33%), of which one isolate showed a monodrug resistance. In total, 9/33 (27%) isolates were resistant to isoniazid. The implications of these findings are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antitubercular Agents / pharmacology*
Chad / epidemiology
Drug Resistance, Bacterial*
Humans
Isoniazid / pharmacology*
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / isolation & purification

Substances

Antitubercular Agents
Isoniazid