A new triterpene and dibenzocyclooctadiene lignans from Schisandra propinqua (WALL.) BAILL

LiJia Xu; Feng Huang; SiBao Chen; ShiLin Chen; PeiGen Xiao

doi:10.1248/cpb.54.542

A new triterpene and dibenzocyclooctadiene lignans from Schisandra propinqua (WALL.) BAILL

Chem Pharm Bull (Tokyo). 2006 Apr;54(4):542-5. doi: 10.1248/cpb.54.542.

Authors

LiJia Xu¹, Feng Huang, SiBao Chen, ShiLin Chen, PeiGen Xiao

Affiliation

¹ Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, P. R. China.

PMID: 16595961
DOI: 10.1248/cpb.54.542

Abstract

A new triterpene and two new natural dibenzocyclooctadiene lignans were isolated from the stems of Schisandra propinqua. In addition, three known lignans, octadecanoic acid, 2,3-dihydroxypropyl ester and beta-sitosterol were isolated. The structures of the new triterpene and new natural products were elucidated base on spectral analysis, including 1D and 2D NMR experiments. The isolates were tested for their cytotoxic effects against several tumor cell lines by MTT assay.

MeSH terms

Antineoplastic Agents, Phytogenic / pharmacology*
Carcinoma, Hepatocellular / pathology
Cell Line, Tumor
Cyclooctanes / chemistry
Cyclooctanes / isolation & purification
Cyclooctanes / pharmacology*
Humans
Inhibitory Concentration 50
Lignans / chemistry
Lignans / isolation & purification
Lignans / pharmacology*
Magnetic Resonance Spectroscopy
Plants, Medicinal*
Schisandra / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Cyclooctanes
Lignans
Triterpenes
dibenzocyclooctadiene