Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS

J Affect Disord. 1991 Aug;22(4):185-90. doi: 10.1016/0165-0327(91)90064-y.

Abstract

In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was used to measure phosphorus metabolism in the brains of manic patients treated with lithium carbonate. The phosphomonoester (PME) peak was elevated in the manic state in patients with DSM-IIIR bipolar disorder compared to the euthymic state and to drug-free normal controls. Elevation of the PME peak may be caused by lithium-induced accumulation of inositol 1-phosphate in the brain.

MeSH terms

  • Adult
  • Arousal / drug effects
  • Arousal / physiology
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / metabolism*
  • Bipolar Disorder / psychology
  • Brain / drug effects*
  • Brain / metabolism*
  • Female
  • Humans
  • Lithium Carbonate / therapeutic use*
  • Magnetic Resonance Spectroscopy*
  • Male
  • Middle Aged
  • Phosphatidylinositols / metabolism*
  • Psychiatric Status Rating Scales

Substances

  • Phosphatidylinositols
  • Lithium Carbonate