Elevated serum müllerian-inhibiting substance may be a marker for ovarian hyperstimulation syndrome in normal women undergoing in vitro fertilization

Gary S Nakhuda; Micheline C Chu; Jeff G Wang; Mark V Sauer; Rogerio A Lobo

doi:10.1016/j.fertnstert.2005.10.052

Elevated serum müllerian-inhibiting substance may be a marker for ovarian hyperstimulation syndrome in normal women undergoing in vitro fertilization

Fertil Steril. 2006 May;85(5):1541-3. doi: 10.1016/j.fertnstert.2005.10.052. Epub 2006 Mar 29.

Authors

Gary S Nakhuda¹, Micheline C Chu, Jeff G Wang, Mark V Sauer, Rogerio A Lobo

Affiliation

¹ Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA. gsn16@columbia.edu

PMID: 16566934
DOI: 10.1016/j.fertnstert.2005.10.052

Abstract

We identified patients who experienced ovarian hyperstimulation syndrome (OHSS) (n = 16) and compared their baseline pretreatment levels of müllerian-inhibiting substance (MIS) to age- and weight-matched patients with normal responses to gonadotropins (n = 14). Baseline serum MIS in patients with OHSS were sixfold higher than those seen in normal controls (3.62 +/- 0.87 vs. 0.63 +/- 0.09 ng/mL; P=.0036), indicating that MIS could potentially serve as a useful marker for identifying patients at risk for OHSS.

Publication types

Controlled Clinical Trial

MeSH terms

Adult
Anti-Mullerian Hormone
Biomarkers / blood
Female
Fertilization in Vitro / adverse effects*
Glycoproteins / blood*
Humans
Ovarian Hyperstimulation Syndrome / blood*
Ovarian Hyperstimulation Syndrome / diagnosis
Ovarian Hyperstimulation Syndrome / etiology*
Prognosis
Risk Assessment / methods*
Risk Factors
Testicular Hormones / blood*

Substances

Biomarkers
Glycoproteins
Testicular Hormones
Anti-Mullerian Hormone