Quantitative evaluation of genetic and environmental parameters determining antibody response induced by vaccination against bovine respiratory syncytial virus

Vaccine. 2006 May 1;24(18):4007-16. doi: 10.1016/j.vaccine.2005.11.049. Epub 2005 Dec 9.

Abstract

The parameters controlling IgG antibody responses induced by vaccination against bovine respiratory syncytial virus (BRSV) were investigated in 463 Holstein-Charolais crossbred cattle. Pre- and post-vaccination sera were tested by enzyme linked immunosorbent assays (ELISA) for BRSV-specific IgG and IgG2. Year-of-birth, age, sex and pre-existing antibody were significant sources of variation for IgG responses. Pre-vaccination, progeny with a higher proportion of Holstein genes had higher total BRSV-IgG. By Day 35 post-vaccination, heritabilities peaked at 0.26 for total BRSV-IgG and 0.36 for BRSV-IgG1. There was no evidence for interbreed differences between Holstein and Charolais calves, post-vaccination. These results suggest that calf-sire has a major heritable influence on serum IgG levels following BRSV immunisation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Antibodies, Viral / blood*
  • Cattle / genetics
  • Cattle / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hybridization, Genetic
  • Immunoglobulin G / blood
  • Male
  • Respiratory Syncytial Virus Vaccines / administration & dosage
  • Respiratory Syncytial Virus Vaccines / immunology*
  • Respiratory Syncytial Virus, Bovine / immunology*
  • Sex Characteristics

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Respiratory Syncytial Virus Vaccines