Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium

DNA Repair (Amst). 2006 May 10;5(5):591-601. doi: 10.1016/j.dnarep.2006.01.006. Epub 2006 Feb 28.

Abstract

The response of cells to DNA damage is critical for maintaining genomic integrity and for preventing cancer development. Current advances in our understanding of the response of cells to DNA double-strand breaks and to stalled DNA replication forks and the relationship of these responses to human disease were discussed at the 52nd Benzon Symposium in Denmark, Copenhagen. Here we review the novel findings that were presented at this Symposium and the current state of the field.

Publication types

  • Congress

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism
  • Checkpoint Kinase 1
  • Chromatin / genetics
  • Chromatin / metabolism
  • DNA Damage*
  • DNA Repair / genetics
  • DNA Repair / physiology
  • DNA Replication
  • DNA-Binding Proteins / metabolism
  • Denmark
  • Genetic Diseases, Inborn / genetics
  • Genetic Diseases, Inborn / metabolism
  • Humans
  • Models, Biological
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Protein Kinases / metabolism
  • Protein Serine-Threonine Kinases / metabolism
  • Telomere / genetics
  • Telomere / metabolism
  • Translocation, Genetic
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Proteins / metabolism

Substances

  • Cell Cycle Proteins
  • Chromatin
  • DNA-Binding Proteins
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • Protein Kinases
  • ATM protein, human
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Checkpoint Kinase 1
  • Protein Serine-Threonine Kinases