The rational design of an AIDS vaccine

Daniel C Douek; Peter D Kwong; Gary J Nabel

doi:10.1016/j.cell.2006.02.005

The rational design of an AIDS vaccine

Cell. 2006 Feb 24;124(4):677-81. doi: 10.1016/j.cell.2006.02.005.

Authors

Daniel C Douek¹, Peter D Kwong, Gary J Nabel

Affiliation

¹ Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Building 40, MSC-3005, 40 Convent Drive, Bethesda, MD 20892, USA.

PMID: 16497577
DOI: 10.1016/j.cell.2006.02.005

Abstract

The extraordinary genetic diversity and immune evasion of human immunodeficiency virus (HIV) pose significant challenges for vaccine development. AIDS vaccine design requires a scientifically driven, rational approach that encompasses the latest advances in viral molecular genetics, structural biology, and immunology.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

AIDS Vaccines* / immunology
Acquired Immunodeficiency Syndrome / immunology
Acquired Immunodeficiency Syndrome / prevention & control*
Acquired Immunodeficiency Syndrome / virology
Antibodies, Viral / biosynthesis
Clinical Trials as Topic
Forecasting
Genetic Variation
HIV-1 / genetics
HIV-1 / immunology*
Humans
Immunity, Cellular
Major Histocompatibility Complex
Models, Structural
Technology, Pharmaceutical*
Viral Proteins / immunology

Substances

AIDS Vaccines
Antibodies, Viral
Viral Proteins

Grants and funding

Intramural NIH HHS/United States