Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg)

Biochem Biophys Res Commun. 1991 Jul 15;178(1):8-15. doi: 10.1016/0006-291x(91)91772-5.

Abstract

Structural definition of the receptors for neurotropic and angiogenic modulators such as fibroblast growth factors and related polypeptides will yield insight into the mechanisms that control early development, embryogenesis, organogenesis, wound repair and neovessel formation. We isolated 3 murine cDNAs encoding different binding domains of these receptors (flg). Comparison of these ectoplasmic portions showed that two of the forms corresponded to previously described murine molecules whereas the third one had a different ectoplasmic portion generated by specific changes in two regions. Interestingly, expression of this third form seems to be restricted in its tissue distribution. Such modifications could influence the ligand specificity of the different receptors and/or their binding affinity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antisense Elements (Genetics)
  • Base Sequence
  • Cell Line
  • DNA / genetics*
  • DNA / isolation & purification
  • Fibroblast Growth Factors / metabolism
  • Filaggrin Proteins
  • Humans
  • L Cells / metabolism
  • Mice
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Receptors, Cell Surface / genetics*
  • Receptors, Fibroblast Growth Factor
  • Ribonuclease, Pancreatic
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic

Substances

  • Antisense Elements (Genetics)
  • FLG protein, human
  • Filaggrin Proteins
  • Oligonucleotide Probes
  • Receptors, Cell Surface
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factors
  • DNA
  • Ribonuclease, Pancreatic