Discovery of novel hydroxy pyrazole based factor IXa inhibitor

Dange Vijaykumar; Paul A Sprengeler; Michael Shaghafi; Jeffrey R Spencer; Brad A Katz; Christine Yu; Roopa Rai; Wendy B Young; Brian Schultz; James Janc

doi:10.1016/j.bmcl.2006.01.123

Discovery of novel hydroxy pyrazole based factor IXa inhibitor

Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. doi: 10.1016/j.bmcl.2006.01.123. Epub 2006 Feb 17.

Authors

Dange Vijaykumar¹, Paul A Sprengeler, Michael Shaghafi, Jeffrey R Spencer, Brad A Katz, Christine Yu, Roopa Rai, Wendy B Young, Brian Schultz, James Janc

Affiliation

¹ Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. dvijayku@hotmail.com

PMID: 16487703
DOI: 10.1016/j.bmcl.2006.01.123

Abstract

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

MeSH terms

Factor IXa / antagonists & inhibitors*
Factor IXa / chemistry
Humans
Models, Molecular
Pyrazoles / pharmacology*
Serine Proteinase Inhibitors / pharmacology*

Substances

Pyrazoles
Serine Proteinase Inhibitors
Factor IXa