Recent advances in combinatorial chemistry applied to development of anti-HIV drugs

Mini Rev Med Chem. 2006 Jan;6(1):91-108. doi: 10.2174/138955706775197820.

Abstract

A compilation of combinatorial chemistry techniques applied to anti-HIV drug development is presented in this review. This synthetic strategy together with high throughput screening assays has allowed the discovery and optimization of novel lead anti-HIV compounds.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Combinatorial Chemistry Techniques / methods*
  • HIV / drug effects
  • HIV / physiology
  • HIV Fusion Inhibitors / chemical synthesis
  • HIV Integrase Inhibitors / chemical synthesis
  • HIV Protease Inhibitors / chemical synthesis
  • Humans
  • Molecular Structure
  • Reverse Transcriptase Inhibitors / chemical synthesis

Substances

  • Anti-HIV Agents
  • HIV Fusion Inhibitors
  • HIV Integrase Inhibitors
  • HIV Protease Inhibitors
  • Reverse Transcriptase Inhibitors