The increased vulnerability of HIV infected children to infections supports the principle of vaccination. This article summarizes the available data on the practice of vaccination among HIV infected children. Vaccination is, in general, harmless and efficacious in those children. The World Health Organisation (WHO) guidelines are very similar to other recommandations. Nevertheless, the HIV related immunosuppression reduces the vaccination benefits. Moreover, serious complications are possible after BCG-vaccine administration in seriously immunocompromised children. Therefore, children with AIDS should not be given this vaccine. The benefits of anti-poliomyelitis and anti-measles vaccination markedly exceed the low post-vaccination risk reported among these children.