Abstract
Among the Candida species, Candida parapsilosis has a unique mitochondrial respiratory network. The addition of inhibitors of the respiratory pathways in three clinical isolates of C. parapsilosis with high (> or =2- microg/ml) MICs of caspofungin significantly (fivefold) decreased caspofungin MICs but did not change fluconazole MICs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / pharmacology*
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Candida / drug effects*
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Candida / metabolism
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Caspofungin
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Echinocandins
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Lipopeptides
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Microbial Sensitivity Tests
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Mitochondria / drug effects*
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Mitochondria / metabolism
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Oxygen Consumption / drug effects*
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Peptides, Cyclic / pharmacology*
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides, Cyclic
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Caspofungin