Sphingolactones: selective and irreversible inhibitors of neutral sphingomyelinase

Angew Chem Int Ed Engl. 2006 Jan 23;45(5):827-30. doi: 10.1002/anie.200501983.
No abstract available

MeSH terms

  • Ceramides / chemical synthesis
  • Ceramides / chemistry
  • Dose-Response Relationship, Drug
  • Enzyme Activation / drug effects
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Lactones / chemical synthesis
  • Lactones / chemistry*
  • Lactones / pharmacology*
  • Molecular Conformation
  • Sphingomyelin Phosphodiesterase / antagonists & inhibitors*
  • Sphingomyelins / chemistry
  • Stereoisomerism
  • Structure-Activity Relationship
  • Time Factors

Substances

  • Ceramides
  • Enzyme Inhibitors
  • Lactones
  • Sphingomyelins
  • Sphingomyelin Phosphodiesterase