"Simple but not simpler": toward a unified picture of energy requirements in cell death

FASEB J. 2005 Nov;19(13):1783-8. doi: 10.1096/fj.05-4200rev.

Abstract

In 1996, Wang and his group empirically disclosed a key role of (deoxy)-ATP in functioning of the apoptotic machinery. After almost a decade, and despite the emerged intricacy of the death pathways, ATP is still considered a key determinant of apoptosis with no apparent active roles in necrosis. Yet recent findings indicate that apoptosis proceeds even without energy and that necrosis can be regulated by ATP-dependent processes. This review strictly focuses on current knowledge on the role of energy in execution of different death programs. A thorough understanding of energy requirements in cell death can help to overcome obsolete dogmas in cell biology, paving the way to a more integrated, albeit not simpler, view of the molecular mechanisms contributing to cell dismantling.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / physiology
  • Animals
  • Apoptosis
  • Apoptotic Protease-Activating Factor 1
  • Biochemistry / methods*
  • Calcium / metabolism
  • Caspases / metabolism
  • Cell Death*
  • Energy Metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Models, Biological
  • Necrosis
  • Proteins / metabolism
  • Signal Transduction

Substances

  • APAF1 protein, human
  • Apoptotic Protease-Activating Factor 1
  • Intracellular Signaling Peptides and Proteins
  • Proteins
  • Adenosine Triphosphate
  • Caspases
  • Calcium