New aristolochic acid, aristololactam and renal cytotoxic constituents from the stem and leaves of Aristolochia contorta

Pharmazie. 2005 Oct;60(10):785-8.

Abstract

Two novel phenanthrene derivatives, aristololactam IVa (1) and 9-hydroxy aristolochic acid I (2) were isolated from the stem and leaves of Anstolochia contorta Bunge, together with 17 known compounds (3-19). The structures of these compounds were determined by spectroscopic analysis. The phenanthrenes obtained were tested for cytotoxicity against renal proximal tubular epithelial cell line (HK-2). Aristololactam IVa and 7-methoxy aristololactam IV were found to have strong cytotoxic activity against HK-2 cells with a potency similar to or even stronger than those of aristolochic acid I and aristololactam I.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aristolochia / chemistry*
  • Aristolochic Acids / chemistry*
  • Aristolochic Acids / isolation & purification
  • Cell Line
  • Humans
  • Kidney / pathology*
  • Kidney Tubules, Proximal / cytology
  • Kidney Tubules, Proximal / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Phenanthrenes / chemistry*
  • Phenanthrenes / isolation & purification
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared

Substances

  • 9-hydroxy aristolochic acid I
  • Aristolochic Acids
  • Phenanthrenes
  • aristololactam IVa
  • aristolochic acid I