Multicomponent synthesis of spiroisoxazolines

Mauro F A Adamo; Donato Donati; Eleanor F Duffy; Piero Sarti-Fantoni

doi:10.1021/jo051181w

Multicomponent synthesis of spiroisoxazolines

J Org Chem. 2005 Oct 14;70(21):8395-9. doi: 10.1021/jo051181w.

Authors

Mauro F A Adamo¹, Donato Donati, Eleanor F Duffy, Piero Sarti-Fantoni

Affiliation

¹ Centre for Synthesis and Chemical Biolog, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland. madamo@rcsi.ie

PMID: 16209583
DOI: 10.1021/jo051181w

Abstract

A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Isoxazoles / chemical synthesis*
Isoxazoles / chemistry*
Molecular Structure
Spiro Compounds / chemical synthesis*
Spiro Compounds / chemistry

Substances

Isoxazoles
Spiro Compounds