Abstract
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Borrelia burgdorferi / genetics*
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DNA, Bacterial
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Drug Resistance, Bacterial / genetics*
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Fluoroquinolones / pharmacology*
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Genes, Bacterial
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Mutation*
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Nucleic Acid Amplification Techniques
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Selection, Genetic
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Sequence Analysis, DNA
Substances
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Anti-Infective Agents
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DNA, Bacterial
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Fluoroquinolones