Abstract
A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D(4) (hD(4)) and 5-HT(2A) receptors. Several compounds displayed selectivity for these receptors versus hD(2) and alpha(1) adrenergic receptors of over 500-fold.
MeSH terms
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Antipsychotic Agents / chemical synthesis
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Antipsychotic Agents / chemistry*
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Antipsychotic Agents / pharmacology*
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Benzamides / chemical synthesis
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Benzamides / chemistry*
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Benzamides / pharmacology*
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Dopamine / chemistry
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Humans
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Ligands
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Receptors, Dopamine D4 / antagonists & inhibitors*
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Serotonin 5-HT2 Receptor Antagonists*
Substances
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Antipsychotic Agents
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Benzamides
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Ligands
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Serotonin 5-HT2 Receptor Antagonists
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Receptors, Dopamine D4
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Dopamine