Abstract
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Atrophy / genetics
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Atrophy / pathology
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Atrophy / physiopathology
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Brain Mapping
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Cerebral Cortex / pathology*
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Cerebral Cortex / physiopathology
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Cognition Disorders / pathology*
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Cognition Disorders / physiopathology
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Cognition Disorders / psychology
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Corpus Striatum / pathology
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Corpus Striatum / physiopathology
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DNA Mutational Analysis
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Female
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Genetic Testing
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Genotype
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Humans
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Huntingtin Protein
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Huntington Disease / genetics
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Huntington Disease / pathology*
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Huntington Disease / physiopathology
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Nerve Tissue Proteins / genetics
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Neuropsychological Tests
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Nuclear Proteins / genetics
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Trinucleotide Repeats / genetics
Substances
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HTT protein, human
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Huntingtin Protein
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Nerve Tissue Proteins
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Nuclear Proteins