Environmental risk factors for Alzheimer's disease: their relationship to age of onset and to familial or sporadic types

A S Henderson; A F Jorm; A E Korten; H Creasey; E McCusker; G A Broe; W Longley; J C Anthony

doi:10.1017/s0033291700030373

Environmental risk factors for Alzheimer's disease: their relationship to age of onset and to familial or sporadic types

Psychol Med. 1992 May;22(2):429-36. doi: 10.1017/s0033291700030373.

Authors

A S Henderson¹, A F Jorm, A E Korten, H Creasey, E McCusker, G A Broe, W Longley, J C Anthony

Affiliation

¹ NH & MRC Social Psychiatry Research Unit, Australian National University, Canberra.

PMID: 1615110
DOI: 10.1017/s0033291700030373

Abstract

Data from a case-control study of Alzheimer's disease (AD) were analysed in relation to age of onset and familial/sporadic status. The analyses were restricted to environmental exposures which might injure the brain. Later-onset AD was found to be positively associated with starvation/malnutrition and with nose-picking and negatively with analgesics, while earlier-onset was associated with physical underactivity and nervous breakdown more than 10 years before. Sporadic AD was associated with starvation/malnutrition and with head injury. These analyses merit replication in other large case-control studies of AD.

MeSH terms

Age Factors
Aged
Alzheimer Disease / diagnosis
Alzheimer Disease / etiology*
Alzheimer Disease / genetics
Brain Damage, Chronic / diagnosis
Brain Damage, Chronic / etiology
Brain Damage, Chronic / genetics
Case-Control Studies
Environmental Exposure*
Female
Humans
Risk Factors
Social Environment*