Abstract
The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Apolipoprotein E4
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Apolipoproteins E / genetics*
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Brain / metabolism
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Brain / physiopathology
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Cognition Disorders / genetics
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Cognition Disorders / physiopathology
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DNA Mutational Analysis
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Disease Progression
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Female
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genetic Variation / genetics
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Heterozygote*
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Humans
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Male
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Memory Disorders / genetics*
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Memory Disorders / physiopathology
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Memory Disorders / psychology
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Middle Aged
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Neuropsychological Tests
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Oxidative Stress / genetics
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Sleep Apnea Syndromes / complications*
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Sleep Apnea Syndromes / genetics*
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Sleep Apnea Syndromes / physiopathology
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Sleep Stages / genetics
Substances
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Apolipoprotein E4
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Apolipoproteins E