All roads lead to FoxO

Michihiro Matsumoto; Domenico Accili

doi:10.1016/j.cmet.2005.03.008

All roads lead to FoxO

Cell Metab. 2005 Apr;1(4):215-6. doi: 10.1016/j.cmet.2005.03.008.

Authors

Michihiro Matsumoto¹, Domenico Accili

Affiliation

¹ Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

PMID: 16054064
DOI: 10.1016/j.cmet.2005.03.008

Abstract

Stress-activated kinases control metabolism by antagonizing the early steps of insulin signal transduction. Two papers now demonstrate that Jnk, the prototypical stress-activated kinase, controls life span in Drosophila and C. elegans by promoting phosphorylation of the forkhead protein FoxO (Oh et al., 2005; Wang et al., 2005). The findings provide yet another mechanism by which metabolic and stress responses are integrated via phosphorylation of FoxO proteins.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans / metabolism
Caenorhabditis elegans Proteins / metabolism*
Drosophila / metabolism
Drosophila Proteins / metabolism*
Forkhead Transcription Factors
Insulin / metabolism*
Mitogen-Activated Protein Kinases / metabolism*
Signal Transduction / physiology*
Transcription Factors / metabolism*

Substances

Caenorhabditis elegans Proteins
Drosophila Proteins
FOXO protein, Drosophila
Forkhead Transcription Factors
Insulin
Transcription Factors
JNK-1 protein, C elegans
Mitogen-Activated Protein Kinases