Synthesis of cationic beta-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1

Bioorg Med Chem Lett. 2005 Jul 15;15(14):3333-7. doi: 10.1016/j.bmcl.2005.05.044.

Abstract

An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents* / chemical synthesis
  • Antiviral Agents* / pharmacology
  • Antiviral Agents* / radiation effects
  • Cations / chemistry
  • Cell Proliferation / drug effects
  • Chlorocebus aethiops
  • Dose-Response Relationship, Drug
  • Drug Design
  • Herpesvirus 1, Human / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Photochemistry
  • Porphyrins* / chemical synthesis
  • Porphyrins* / pharmacology
  • Porphyrins* / radiation effects
  • Structure-Activity Relationship
  • Ultraviolet Rays
  • Vero Cells
  • Vinyl Compounds* / chemical synthesis
  • Vinyl Compounds* / pharmacology
  • Vinyl Compounds* / radiation effects

Substances

  • Antiviral Agents
  • Cations
  • Porphyrins
  • Vinyl Compounds
  • tetraphenylporphyrin