Abstract
We investigated the expression of insulin-like growth factor-1 receptor (CD221) in normal, reactive and malignant plasma cells. We show that CD221 is aberrantly expressed on human myeloma cells, that higher levels of CD221 are observed in patients and human myeloma cell lines with the most aggressive 14q32 translocations, and that CD221 expression has a negative prognostic impact in patients with multiple myeloma.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Bone Marrow / chemistry
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Cell Line, Tumor / metabolism
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Cell Line, Tumor / pathology
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Chromosomes, Human, Pair 14 / genetics*
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Chromosomes, Human, Pair 14 / ultrastructure
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Chromosomes, Human, Pair 16 / genetics
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Chromosomes, Human, Pair 16 / ultrastructure
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Chromosomes, Human, Pair 4 / genetics
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Chromosomes, Human, Pair 4 / ultrastructure
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Humans
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Life Tables
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Multiple Myeloma / genetics
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Multiple Myeloma / metabolism*
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Multiple Myeloma / mortality
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Multiple Myeloma / pathology
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Palatine Tonsil / chemistry
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Plasma Cells / chemistry*
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Plasma Cells / pathology
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Prognosis
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Receptor, IGF Type 1 / biosynthesis*
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Receptor, IGF Type 1 / genetics
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Survival Analysis
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Translocation, Genetic*
Substances
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Neoplasm Proteins
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Receptor, IGF Type 1